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Some protocols incorporate topical application to specific areas of concern alongside injectable administration for localized plus systemic benefits

[91] Based on its structure-activity relationships, several analogues of FISLE-412 have been developed and found to neutralize anti-lupus antibodies in vitro and ex vivo

It can also be reconstituted in 0.9% acetic acid (diluted) if improved solution stability is needed for specific protocols, though bacteriostatic water is the standard